How melanin protects and darkens skin
Your skin color comes from melanin, a pigment made by cells called melanocytes. Melanin works like a natural shield. It absorbs UV radiation and neutralizes free radicals, protecting the deeper layers of your skin. When you’re out in the sun, your skin kicks that defense into gear. It makes more melanin in three distinct stages: immediate pigment darkening, persistent pigment darkening, and delayed tanning.
The role of UV exposure
Ultraviolet light is the biggest trigger of pigmentation changes. UVA rays darken existing melanin right away. UVB rays go further and trigger new melanin production, through DNA-damage pathways involving p53 and other molecular signals. That’s why tanning, sun spots and freckles show up after time in the sun, especially without consistent protection.
Hormones, inflammation, and medications
Not all pigmentation comes from the sun. The American Academy of Dermatology (AAD) points to other common causes too. Hormonal shifts like pregnancy or contraceptives, chronic inflammation from acne or eczema, and certain medications can all play a part. These factors over-activate your melanocytes, which can lead to melasma or post-inflammatory hyperpigmentation.
Summary: Key Pigmentation Triggers
- Sunlight (UVA & UVB): main cause of increased melanin production
- Hormonal changes: pregnancy, contraceptive use
- Inflammation: acne, skin injury, irritation
- Medications: certain drugs that sensitize or overstimulate pigment cells
| Pigmentation Type | Common Cause | Typical Appearance | Reference |
|---|---|---|---|
| Sunspots / Age Spots (Lentigines) | UV exposure (UVA/UVB) | Flat brown patches on sun-exposed skin | [1][2] |
| Melasma | Hormonal shifts, UV light | Symmetrical brown/gray patches, often on face | [3] |
| Post-inflammatory Hyperpigmentation (PIH) | Acne, injury, irritation | Dark marks where skin healed from inflammation | [3] |
| Freckles (Ephelides) | Genetic tendency, sun exposure | Small brown spots, more visible in summer | [4] |



